In his speech to Tory delegates in Manchester, Cameron said: "Thousands of words have been written about the new Labour leader. But you only really need to know one thing: he thinks the death of Osama bin Laden was a 'tragedy'."
"No," Cameron said, adding, "A tragedy is nearly 3,000 people murdered one morning in New York. A tragedy is the mums and dads who never came home from work that day. A tragedy is people jumping from the towers after the planes hit.
"We cannot let that man inflict his security-threatening, terrorist-sympathising, Britain-hating ideology on the country we love," the Prime Minister said.
But while delegates in the conference hall gave Cameron a standing ovation for his assertion, critics have said he took Corbyn's words out of context.
The Prime Minister was apparently referencing an interview Corbyn did in 2011, in which he said bin Laden's killing was "an assassination attempt, and is yet another tragedy, upon a tragedy, upon a tragedy".
Yet the then-backbencher MP added: "The World Trade Centre was a tragedy, the attack on Afghanistan was a tragedy, the war in Iraq was a tragedy."
Cameron also criticised Corbyn's economic proposals, citing the Labour leader's economic adviser, Richard Murphy.
Saying Murphy was "very frank" in a recent interview, the Prime Minister added: "He admitted that Labour’s plan would cause a 'sterling crisis', to be fair, but he did add, and I quote, that it 'would pass very quickly'."
"His book is actually called 'The Joy of Tax'" Cameron added.
"I’ve read it. It’s got 64 positions – and they’re all wrong."