John Lewis boss quits after warnings of ‘really tough’ trading August 10, 2026 The boss of John Lewis’ department stores has quit after less than three years in charge, days after the group’s chair warned of “really tough” trading at the retail giant. Peter Ruis has said he will step down as managing director of John Lewis at the start of September, less than three years after he [...]
Silence Therapeutics Announces Positive Topline Results from Phase 2 SANRECO Trial of Divesiran in Polycythemia Vera, Supporting its Potential Best-in-Class Profile August 10, 2026 Trial met its primary endpoint, with a significantly higher proportion of clinical responders on divesiran (88%) compared to placebo (19%); placebo-adjusted response rate = 69% Both divesiran dose groups showed substantial primary endpoint efficacy; 93.8% response rate at Q6W and 81.3% response rate at Q12W Divesiran was observed to be well tolerated with no new safety findings Phase 3 PV trial evaluating divesiran Q12W vs. placebo anticipated to initiate in 1H’27 Investor conference call and webcast to be held today, August 10, 2026 at 8:00 a.m. ET
Silence Therapeutics Reports Second Quarter 2026 Financial and Business Results August 10, 2026 Silence Therapeutics plc, (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial and business results for the second quarter ended June 30, 2026. Business Highlights Divesiran: First-in-class siRNA silencing TMPRSS6 for polycythemia vera (PV) and other blood disorders Presented follow-up data from the Phase 1 SANRECO trial [...]
Vistry shares slide after Allianz ‘cuts insurance cover’ August 10, 2026 Shares in Vistry fell on Monday morning after speculation over its insurance cover prompted fresh fears that the housebuilder is facing cash struggles. The FTSE 250 housebuilder saw its stock slide by nearly eight per cent to 261p in early trading, meaning the firm has shed more than half of its market value in the [...]
Prem Rugby team ditch Big Game fixture at Premier League ground August 10, 2026 Prem Rugby club Gloucester have cancelled a planned fixture at Aston Villa’s Villa Park after its inaugural staging last season was criticised by fans. A Slater Cup fixture between Gloucester and Leicester Tigers was held at the Premier League ground last season, with a number of discounted tickets helping the attendance top 20,000 – around [...]
As it happened: Intel, Arm shares slide; Oil climbs higher August 10, 2026 Welcome back to the City AM liveblog. Oil is starting the new week higher and making its third consecutive session for gains after optimism for a peace deal between the US and Iran stalled over the weekend and uncertainty around the Strait of Hormuz persisted. Donald Trump has said the US is “low-keying it” with Iran, [...]
Burnham facing calls to cut employment red tape as job seekers grow for 41 months August 10, 2026 The government is facing calls to strip red tape around employment after the pool of people looking for jobs in the UK grew for a 41st consecutive month. The number of people on the hunt for work has now grown for nearly three and a half years while the number of available jobs has declined [...]
How Britain can stay clear of rivals as home of overseas sport club owners August 9, 2026 Sport is more political than ever. Matt Sutton asks how clubs navigate the geopolitical risks in 2026. Ownership and investment have become increasingly international, with sports clubs, leagues and governing bodies relying on global capital to drive growth. For years an argument has been rumbling on about whether it’s right to have foreign investment in [...]
Why the Loire Valley is about so much more than fairytale castles August 8, 2026 Beyond the Loire Valley’s fairy-tale châteaux, a gentler side of this celebrated destination awaits. Lucy Daltroff dives in It takes just over an hour to fly from Stansted to Tours in the Loire Valley and soon I am eating a spectacular lunch and drinking local wine at the rooftop La Belle Vue Restaurant. Before me [...]
Back to basics: Sainsbury’s gradual retreat from the British high street August 8, 2026 Sainsbury’s deal to sell its catalogue retailer Argos marks the latest step in the grocer’s years-long retreat from a high street conglomerate back to its core food business. The FTSE 100 supermarket giant holds a 15 per cent market share of grocery stores, second only to Tesco. But the firm once had a sprawling business [...]