Prothena Announces Novo Nordisk Obtains Fast Track Designation from the U.S. FDA for Coramitug (PRX004) in ATTR Amyloidosis with Cardiomyopathy April 27, 2026 Coramitug is a potential best-in-class amyloid depleter antibody for the treatment of ATTR amyloidosis with cardiomyopathy1-3 Coramitug is being evaluated by Novo Nordisk in the ongoing Phase 3 CLEOPATTRA clinical trial in ~1280 participants with ATTR-CM; primary completion expected in 2029 The Fast Track Designation underscores the unmet need within ATTR-CM and could expedite the review of coramitug
Golden partnership perks? Not anymore, say the Big Four April 27, 2026 As the Big Four giants grapple with profitability challenges, the traditional partnership model is undergoing significant change to prevent the profit pool from being diluted. The traditional dream at professional services firms – joining, working hard and climbing the ladder to partnership within an LLP structure – now looks very different at the Big Four [...]
UK eyes AI in classrooms as schools face staffing strain April 27, 2026 Advances in AI are moving higher up the UK education agenda, as ministers look for ways to manage teacher shortages without major increases in spending. While the government has so far erred on the side of caution compared to its global peers, the direction of travel is toward a wider use of AI tools in [...]
Inaugural Arab Women Week concludes in London April 27, 2026 London hosted the inaugural Arab Women Week from April 14 to 18, 2026, to celebrate global female leadership and investment. The first Arab Women Week concluded in London on 18th April, following a series of events focused on business and innovation. Over 700 delegates, including royals and ambassadors from 12 embassies, gathered for the occasion [...]
Four Champ Rugby clubs in talks with new investors April 27, 2026 Nearly a third of Champ Rugby clubs are having conversations with potential new investors, as the wider game looks to capitalise on the incoming franchising of Prem Rugby. Although details are still to be finalised, the English top flight is set to steamroll into an expansionist league much like those seen in North America. Red [...]
Lady Mayor: ‘Lawless London’ narrative is risking vital global deals April 27, 2026 Misperceptions of London as dangerous and unwelcoming are sending the wrong signals to vital partners like India, writes Susan Langley.
Race a McLaren at the UK’s most exhilarating track day April 27, 2026 At the UK’s most exciting track day, you can sample a McLaren GT4 race car, a Formula 3000 single-seater and much more, says Tim Pitt The gift was kindly meant, but I found it hard to hide my disappointment. Some 20 birthdays ago, my parents bought me a supercar experience. You know the sort of thing: [...]
Economy could suffer for eight months after Iran war ends, minister says April 26, 2026 Surging food and energy prices caused by the Iran war could last for more than eight months after the conflict ends, Starmer’s right-hand man has said. Higher petrol, food and plane ticket prices will persist for “eight-plus months” following the end of the conflict, chief secretary to the Prime Minister Darren Jones said. The minister [...]
Italy and UK risk driving Formula 1 away with misguided tax raids April 26, 2026 Italy’s latest attempt to claw back tax from Formula 1 drivers and teams is being framed as a crackdown on evasion. In reality, it looks far more like a system struggling to keep up with the modern sport it is trying to regulate. Authorities are reportedly looking to audit teams and drivers retrospectively between 2020 [...]
Spare us Zack Polanski and Zohran Mamdani’s empty progressivism April 25, 2026 Mamdani’s victory in New York proves it’s time to take Zack Polanski and the Green Party seriously. That means recognising how much their policy platform depends on wishful thinking and fantasy economics, says Eliot Wilson Harold Wilson, perhaps Labour’s wiliest Prime Minister, supposedly coined the phrase “a week is a long time in politics”. It [...]