The 38-year-old missed the first game of the five-match one-day series, which ended in a rain-affected draw at Durham, and will now have to wait until the one-day series against England in October, on home soil, to reach the landmark of a century of centuries.
The Little Master struggled for form during the Test series, passing 50 only twice, in which his side were comprehensively beaten 4-0.
Tendulkar, who is expected to be out for a month, becomes the eight high-profile member of Duncan Fletcher’s squad to have flown home early and has been replaced by Subramaniam Badrinath ahead of today’s match at the Rose Bowl.
“It was the injury that he had in 2001 and it flared up in Durham,” said an Indian team official. “He went to a specialist in London and we got the news he would not be taking any further part in the one-day series anymore and he might need rest for four to six weeks.”