The Royal Exchange is to become home to five new luxury brands.
Aspinal of London, Grind & Co, Orlebar Brown, Halcyon Days and TD Tom Davies are taking space in the Grade I listed building.
Oxford Properties bought the 16th century landmark in 2013 and this is the second set of retailers to move in since then.
At the end of last year, Oxford Properties brought Leica, E. Marinella and Georg Jensen to The Royal Exchange.
TD Tom Davies, a luxury glasses retailer, is opening its fourth store in The Royal Exchange.
CBRE acted as the leasing agent for Oxford Properties on the most recent deal.
Executive director of central London retail at CBRE, Steven Stedman, said: "The Royal Exchange is part of the very fabric of London and its bustling location makes it an ideal base for both luxury retailers and exciting restaurant brands.
"The five new tenants will further enhance what is already a diverse offering."
Jonathan Harley, associate asset manager at Oxford Properties, said: "We are delighted to announce so much activity over the last nine months. The Royal Exchange is home to an unrivalled collection of contemporary and luxury brands, and is where the City converges to meet, eat and shop."