In a statement today the retailer said Laura Wade-Gery, its executive director of multi-channel, will not return from maternity leave.
Wade-Gery, who oversaw the rocky launch of M&S' website last year, will step down from the board immediately, and will leave the company at the end of September.
However, Bolland stepped down in January, replaced by Steve Rowe - and in May this year the retailer engaged in a major shake-up of its management team, with Patrick Bousquet-Chavanne becoming executive director of customer, marketing and M&S.com, while chief financial officer Helen Weir took on responsibility for strategy implementation.
"Laura has been a great colleague and has achieved much in her role heading our multi-channel business. I am grateful to Laura for her contribution and she leaves M&S with my personal thanks and best wishes," said Rowe today.
"I have had five very happy years at M&S. I've been away from the business for a year now, and that time has seen some significant changes in both my personal life and in the business. I concluded that the time was right to move on from M&S. I wish Steve and all my colleagues and friends every success," Wade-Gery added.
M&S shares generally had a bad day, and were trailing 4.5 per cent at 328.1p shortly before the market close.