The group posted Asian sales last year of £11bn from consumers in South Korea, China, Japan, Malaysia, Thailand and India.
Tesco is the first FTSE 100 company to open such a training academy in Asia.
Workers will be taught a range of skills for the shop floor as well as online and administration tasks.
Its water-front academy is close to Incheon international airport, which serves Seoul.
Some 24,000 Tesco employees will attend training courses there each year.
The campus also includes a Tesco museum to give international staff information about the history of the company, and highlights the importance of Asian markets to international retailers. South Korea is one of Tesco’s biggest international markets.