Redknapp has prioritised signing a forward as he looks to reverse his new club’s disastrous start to the season and drag them off the bottom of the Premier League.
Defoe, 30, has been mooted as a target, having been signed by Redknapp for Portsmouth and Spurs, and made his senior debut under him at West Ham.
But he said: “That’s not going to happen. I’m not leaving Tottenham, I love the club and to score goals at a big club like this is fantastic.
“I think I can say I’d like to finish my career at Tottenham. I want to achieve something special here.”
Spurs boss Andre Villas-Boas has declared his intention to hold onto Defoe, who has 12 goals this season, comparing him to sought-after Atletico Madrid star Falcao.
Redknapp has admitted he would gladly welcome £24m Aston Villa outcast Darren Bent to QPR, despite selling him while Tottenham boss and publicly deriding him for missing a chance by saying “my missus could have scored”.