The main package is a £70m development fund to attract new business and new jobs to the capital.
A further £15m will be spent making road junctions, such as Waterloo roundabout, safer for cyclists.
Airport expansion is once again a possibility with the chancellor saying that the government “must confront” the lack of capacity in the South East.
There will also be an enterprise zone in the Royal Docks, superfast broadband and backing for new river crossings in East London.
With just five weeks to go until the mayoral election Johnson will claim the deal proves he is best the best-placed candidate to access central government funding.