Kamaluddin, who has been in his role since 2009 after about five years as finance director, has led the retailer’s rapid expansion into international markets.
Asos’s overseas business accounted for 61 per cent of sales in the first half of the year and rose 39 per cent to £214m in the period.
The firm said Kamaluddin will step down from the board in October before leaving in December after handing over the company to his successor.
The search for his successor is currently underway, Asos said.
Nick Robertson, chief executive said: “Personally and on behalf of all of us at Asos I want to thank him for his outstanding contribution to our success and wish him well in the future.”