Matt Hankin, Jack Wilson, Jackson Wray, Jamie George, Nathan Earle and Tim Streather crossed over while Ben Spencer notched 17 points from the tee.
And Sanderson hinted England returnee Farrell could be in line for a rest, such was the dominance of Hodgson.
“He’s been out for so long but it looked so easy for him to get back on the bike,” said Sanderson.
“The timing of his passes was top class, the way he put Jack Wilson through for his try was superb.
“Owen might get a week off now, we’ll see what he wants to do.”
Glenn Dickson hit six penalties for Northampton Saints as London Irish fell to a 39-18 defeat at the Madejski Stadium.
And assistant coach Glenn Delaney admits their penalty count cost the team dearly.
“We chipped away and got within striking distance with 25 minutes to go,” said Delaney.
“But we kept conceding penalties in vital areas, which did seem somewhat harsh.”
Harlequins director of rugby Conor O’Shea believes Sale Sharks’ veterans, led by former England man Danny Cipriani, used their experience to slip away with a narrow 31-26 win on Friday.
“We were against a very experienced Sale side that came down here so we knew we were up against it,” said O’Shea. “But I thought we responded to the challenge which is what we want.”
Elsewhere, Dai Young’s London Wasps were beaten by Newport Gwent Dragons 20-8 to end their challenge in the competition.
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