Pressure is mounting on Transport for London to ban cars from Oxford Street during the day.
The New West End Company, which represents the West End area, is calling for Oxford Street to be traffic free between 10am and 10pm.
However, some of the routes running north and south across Oxford Street should stay open, the group said.
The West End stations of the Elizabeth Line are due to open next year. The new transport openings are expected to draw an extra 60m visitors a year from 2020 onwards, presenting a significant challenge to crowd management in the district.
The New West Company has made its proposal for a traffic-free Oxford Street as part of a submission to a consultation on the area, which is being undertaken by Transport for London and Westminster City Council.
Jace Tyrrell, chief executive of the New West End Company, said: "Oxford Street is the nation's high street and it is vital for the West End that it remains a world-class area.
"Traffic-free zones across the West End, and particularly Oxford Street, would make a huge difference to the area and improve the experience of workers, visitors and residents alike. But this must be achieved through removing traffic from the West End, not simply diverting it down neighbouring streets."
The calls come after the City of London Corporation made its first significant step towards removing all vehicles from Bank junction.
Since 22 May the junction has been closed to all vehicles apart from buses between 7am and 7pm.