City minister and economic secretary to the Treasury Simon Kirby has lost his Brighton Kemptown seat.
Labour's Lloyd Russell-Moyle ousted the incumbent MP with a majority of just under 10,000.
The seat had been a Labour target after Kirby triumphed in the 2015 election with a slim 690 majority.
The night has been full of surprises, with Labour defending a host of Conservative targets, while the Tories have been hoovering up SNP seats.
Kirby's loss comes after housing minister Gavin Barwell was also ousted, another Conservative minister to lose his seat tonight, being defeated in Croydon Central by Labour.
Labour meanwhile have been holding firm in London, sweeping many of the key marginals in the capital.
Kirby was handed the role of economic secretary to the Treasury after the Brexit vote when May came to power.