St Katharine Docks, the marina near Tower Bridge, is on the market for £435m.
The docks are part of private equity firm Blackstone's global portfolio, which is worth a total £77bn. The redeveloped port dates back to 1828 and is now home to various shops and restaurants.
CBRE and GM Real Estate are advising Blackstone on the sale.
It is not known who is in line to buy the central London marina, but prime property in the UK capital has become particularly attractive to Chinese buyers due to the fall in the value of the pound.
Blackstone and CBRE declined to comment.