The House of Commons has voted overwhelmingly in favour of a June election, setting the UK on course for a poll just under three years early.
May needed just 434 of the 650 MPs to endorse a June vote. The Commons voted 522 - 13 in favour.
Of the 13 MPs to reject an early election, nine came from Labour, with the remaining four split between Northern Irish and Scottish MPs.
And the figures voting in favour of May's plan included the departing George Osborne.
The vote came after 90 minutes of debate in the House of Commons, with May kicking off proceedings.
The Prime Minister reiterated her belief that a General Election was "in the national interest", and stressed that Britain had "a brief window of opportunity" for a vote before Brexit talks begin.
"Securing the right deal for Britain is my priority and I'm confident that we have the right plan to do it," she said.
Responding, Labour leader Jeremy Corbyn questioned why May and her officials had repeatedly denied any intention to seek an early vote, but welcomed the opportunity to go the public.
"It gives the British people the chance to vote for a Labour government that will put the interests of the majority first," he said.