Hampshire leg-spinner Mason Crane claimed 4-39 as South completed a whitewash of North with a 20-run victory in the final one-day tussle of their three-match series in Abu Dhabi.
The 20-year-old produced a devastating spell to dismiss Sam Hain, Liam Livingstone, Joe Clarke and Jack Leaning as North were bowled out for 208 in a clash reduced to 40 overs per side due to rain.
South had earlier posted 228-8 from their allocation as Kent opener Daniel Bell-Drummond top scored with 81, while Toby Roland-Jones weighed in with 43 during a late cameo.
The clash also witnessed a second outing in the space of five days for England and Durham seamer Mark Wood, who is returning following three ankle operations, and he claimed 2-38 from his eight-over allocation.
But it was right-armer Crane who stole the headlines as he snared four wickets for one run in 10 balls as North slipped from 146-2 to 157-6 in less than four overs.
Livingstone was the key wicket to fall as he departed, stumped by Surrey’s Ben Foakes for 50, while Hain of Warwickshire and Northamptonshire’s Ben Duckett failed to build on promising starts of 44 and 37 respectively.
Surrey all-rounder Tom Curran, who received his senior international call-up for England during their recent tour of the West Indies, also picked up three wickets.