"Two years on from the historic vote of 2014, the fundamental case for Scotland’s independence remains as it was," she said writing in the Sunday Herald.
"The case for full self-government ultimately transcends the issues of Brexit, of oil, of national wealth and balance sheets and of passing political fads and trends."
Sturgeon has said previously that a second Scottish independence referendum is "highly likely" in the wake of Brexit and has sought a good deal for the country which voted for Remain.
The Scottish leader has met with Prime Minister Theresa May to discuss what Brexit means for Scotland, and indicated there were several options for the country - including remaining a part of Europe and a non-member UK.
Sturgeon told the Sunday newspaper that polling put support for Scottish independence higher than two years ago when the vote took place.
Her predecessor Alex Salmond yesterday guessed a second referendum would take place in the autumn of 2018 while Scottish Labour leader Kezia Dugdale insisted the party was against a second vote.
“Make no mistake: there will be no support for a second independence referendum from Scottish Labour," she said, writing in the Times.