The tech firm has made self-driving Ubers available for the first time in the US city - although they will come with a safety driver "to make sure the ride goes smoothly". The launch follows a trial carried out in May.
Uber is testing its driverless technology after setting up an advanced technologies centre (ATC) in Pittsburgh a year and a half ago. It also recently partnered with Volvo to invest $300m (£227m) in building driverless cars.
"This pilot is a big step forward," Anthony Levandowski, VP of self-driving technology at Uber, said today.
"Real-world testing is critical to the success of this technology. And creating a viable alternative to individual car ownership is important to the future of cities."
The company said self-driving Ubers "have enormous potential to further our mission and improve society" - this will be achieved by reducing traffic accidents, freeing up the "20 per cent of space in cities currently used to park the world's billion plus cars", and cutting congestion.