Kane has not scored for 10 matches, since England’s pre-European Championship warm-up clash with Turkey at the City of Manchester Stadium in May.
The 23-year-old endured a similarly slow start to last season and went seven Premier League matches before breaking his duck, yet ended the campaign with 25 top-flight goals.
“It is about patience, time and hard work from him and I am sure he will start to score again,” said Pochettino. “He is starting to be much better.
“It was the same at the end of the 2014-15 season. He went away with England Under-21s and the expectation was to win the European Championships. But he didn’t score in three games and it was a big disappointment for him.
“Now it is the same situation but he is more mature and more experienced. It is a different period in his life and there is no doubt he will start to score again.”
Goalkeeper Hugo Lloris is set to return after suffering a hamstring injury on the opening day of the season, although full-back Danny Rose is ruled out with the same injury.