The banking software developer, which is owned by US buyout firm Vista Equity Partners, is planning a £5.5bn initial public offering (IPO).
Read more: Misys could return to the stock exchange
City A.M. has confirmed a report that Misys has appointed investment adviser Moelis to oversee the float.
The Sunday Times first reported Misys was plotting the IPO, which would be London’s biggest since Worldpay’s £6bn IPO in October last year.
Misys and Moelis have declined to comment.
This year has been a slow one for flotations, particularly by larger companies. While listings on the alternative investment market (Aim) are up on last year, activity is significantly down on the main market.
Experts have pointed to uncertainty around the EU referendum in the first half of the year as one reason. And since the Brexit vote, some firms have withdrawn plans for IPOs.