After the 26-year reign of Sir Alex Ferguson, the third new manager in four years will take his seat in the home dugout of Old Trafford on Friday evening.
Manchester United fans will hope Jose Mourinho’s tenure is far happier than those of David Moyes and Louis van Gaal.
The former Chelsea man has got off to a good start, winning the Community Shield against Leicester, before a comfortable 3-1 Premier League opening day victory over Bournemouth last weekend.
New signings Zlatan Ibrahimovic and Eric Bailly seem to have gelled immediately – and world record signing Paul Pogba could make his debut tonight.
It’s all gone to plan so far for Mourinho, and he’ll hope for three points against a Southampton side who also have a new man in charge.
Claude Puel has big shoes to fill after a successful spell at St Mary’s by Ronald Koeman.
The ex-Lyon and Nice manager began life in England with a 1-1 draw at home to Watford, which was solid, if not spectacular.
Southampton have grabbed two 1-0 victories at Old Trafford in the last two seasons, but they’ll have to improve greatly to manage a similar result again.
I can’t look beyond the 4/9 offered by Betway for a United victory.
Ibrahimovic has scored in both of his competitive appearances so far and will be itching to impress his new home fans.
Pogba too will be eager to make a positive start after re-signing from Juventus for £89m and, between them, the pair could put on a real show.
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Man United 4/9 (Betway)
Buy total goals 2.75 (Sporting Index)