England will be without James Anderson in the Boxing Day Test against South Africa in Durban after the pace bowler was ruled out through injury.
Anderson was unable to reach full fitness in time for the first Test after struggling with a calf injury.
England's leading wicket-taker missed England's second warm-up game against South Africa A in Pietermaritzburg earlier this week and was ruled out for next week's Test after going for a scan on his right leg on Monday.
England head coach Trevor Bayliss said Stuart Broad and other England bowlers would be able to pick up the slack in Anderson's absence.
Two of Steven Finn, Chris Woakes, Chris Jordan or Mark Footitt will join Broad in England's bowling attack.
Bayliss said: "From Stuart's [Broad] point of view we've got an obvious replacement as leader of the attack there and I'm sure he would show that he could handle that as he did against Australia in the fourth Test.
"It's always a concern if your leading bowler or leading batter misses a game, but the last time Jimmy missed one we did pretty well, so you never know."